Establishment of harmonized international reference ranges for plasma estradiol concentrations in postmenopausal women.

Jinghan Cui; Susan E Hankinson; Alvin M Matsumoto; Richard J Santen; Maegan E Boutot; Jeffrey R Budd; Mitch Dowsett; Matthew P Goetz; Catherine Guranich; Serena Houghton; James N Ingle; Micheal E Jones; Sabina Rinaldi; Bernard Rosner; Minouk J Schoemaker; Ravinder J Singh; Hubert W Vesper; A Heather Eliassen; Roger L Milne; Anthony J Swerdlow; Celine M Vachon; Harriet Richardson; Jing Qian

Journal article

Establishment of harmonized international reference ranges for plasma estradiol concentrations in postmenopausal women.

Jinghan Cui, Susan E Hankinson, Alvin M Matsumoto, Richard J Santen, Maegan E Boutot, Jeffrey R Budd, Mitch Dowsett, Matthew P Goetz, Catherine Guranich, Serena Houghton, James N Ingle, Micheal E Jones, Sabina Rinaldi, Bernard Rosner, Minouk J Schoemaker, Ravinder J Singh, Hubert W Vesper, A Heather Eliassen, Roger L Milne, Anthony J Swerdlow Show all

J Clin Endocrinol Metab | Published : 2026

DOI: 10.1210/clinem/dgag188

Abstract

CONTEXT: Prior reports of plasma estradiol concentrations and their reference ranges in postmenopausal women identified marked variation, in part due to assay method and body mass index (BMI). OBJECTIVE: To develop an international reference range for plasma estradiol in postmenopausal women, support accurate assessment of concentrations during systemic and local (eg, vaginal) estradiol therapy, and improve risk prediction for diseases, including osteoporosis, breast, and endometrial cancers. METHODOLOGY: Estradiol concentrations were measured using primarily liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays in 5 international cohorts of community-dwelling, postmenopausal wome..

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